![]() This led to the conclusion that liquisolid technique efficiently improved the drug solubility and dissolution rate of BCS class II drugs. ![]() Thus, we expand upon the transporter effects listed in Fig. Results showed that liquisolid tablet prepared using labrasol/labrafil (1:1) mixture as a liquid vehicle containing 10% ritonavir is a compatible formula with a higher dissolution rate (100% in 35 min). About 98 of BDDCS Class 1 drugs were found to be markedly distributed throughout the brain this includes 17 BDDCS Class 1 drugs known to be P-gp substrates. The formula of higher dissolution rate was subjected to solid state characterization using Differential Scanning Calorimetric (DSC), Infrared Spectroscopy (IR). The prepared liquisolid tablets were fully evaluated, and the dissolution rate at pH 1.2 was investigated. The liquidsolid technique was applied to prepare ritonavir per-oral tablets of high dissolution rate using versatile non-ionic surfactants of high solubilizing ability as liquid vehicles at different drug concentrations (10–30%) and fixed (R). In this work, the effect of solubility increase at the main absorption site for these drugs was investigated using ritonavir as a drug model. ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF BCS CLASS II DRUG RITONAVIR USING LIQUISOLID TECHNIQUE AbstractīCS class II drugs usually suffer inadequate bioavailability as a dissolution step is the absorption rate-limiting step. ![]()
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